Melatonin Use Linked to Increased Heart Failure Risk
A recent study indicates that adults with insomnia who use melatonin long-term face a significantly higher risk of heart failure. Those taking melatonin for at least one year had a 90% greater chance of developing heart failure compared to non-users.
Study Details and Findings
The research analyzed health records of over 130,000 adults with insomnia and no previous history of heart failure. It compared individuals using melatonin for more than a year against similar individuals who never used the supplement.
- Long-term melatonin users had nearly double the risk of developing heart failure within five years.
- These users were also approximately 3.5 times more likely to be hospitalized due to heart failure.
- The study also found a higher risk of death from any cause during the five years following prolonged melatonin use.
Regional Differences in Melatonin Access
In the United Kingdom, melatonin is available only by prescription. Despite this, individuals with at least two prescriptions filled 90 days apart demonstrated an 82% elevated risk of heart failure.
"Adults with insomnia who took melatonin for at least a year had a much higher chance of developing heart failure."
"Long-term users were nearly 3.5 times more likely to be hospitalized for heart failure compared with nonusers."
Use and Popularity of Melatonin in the US
Melatonin is among the most common over-the-counter sleep aids in the United States, with nearly six million Americans using it to fall asleep faster or prolong sleep.
American Heart Association Presentation
The findings were presented at the American Heart Association (AHA) Scientific Sessions 2025, highlighting serious concerns regarding long-term melatonin consumption.
Author's Summary: Long-term melatonin use in adults with insomnia is linked to nearly double the risk of heart failure and significantly higher chances of hospitalization and death within five years.